Introduction: Implementing HIV pre-exposure prophylaxis in the Educational Toys U.S.is critical to decreasing HIV transmission.However, regional disparities in pre-exposure prophylaxis use exist, with the southern U.S.having the lowest uptake relative to need.Community-based organizations in the South provide pre-exposure prophylaxis to many consum
The concept of "field cancerization" was first introduced by Slaughter in 1953 when studying the presence of histologically abnormal tissue surrounding oral squamous cell carcinoma.It was proposed to explain the development of multiple primary tumors and locally recurrent cancer.Organ systems in which field cancerization has been described since th
As a component of the spliceosome, U1 small nuclear ribonucleoproteins (U1RNPs) play critical roles in RNA splicing, and recent studies have shown that U1RNPs could recruit long non-coding RNAs (lncRNAs) to chromatin which are involved in cancer development.However, the interplay of U1 snRNP, lncRNAs and downstream genes and signaling pathways are
Pembrolizumab is an immune checkpoint inhibitor (ICI) that targets the programmed cell death (PD)-1 receptor.It significantly increases the overall Leisure Trousers survival in patients with locally advanced or metastatic urothelial cancer.However, its administration may induce serious immune-related adverse effects, such as myocarditis and myasthe